Crispin completed his PhD at the Australian National University. His first postdoctoral fellowship was at Arizona State University where he studied the interaction of respiration and photosynthesis in cyanobacteria. In 2000 he moved to CSIRO in Canberra, Australia. He has had a diverse range of interests: carotenoid biosynthesis in cereal grains, how manipulation of protein content and composition impacts end product functionality, the genetics of end product quality in wheat and modification of grain composition for health benefits. He is currently the Group Leader of the New Markets Group at CSIRO.